Research Activities

Our lab is focused on the design of new biomaterials, the investigation of strategies for the repair or replacement of damaged tissues, and the development of innovative drug delivery systems. We always welcome undergraduates, graduate students, and researchers with background in fields such as pharmacy, chemistry, and biology to apply and join our research team. For more information, please contact Prof. Dr. Achim G?pferich and submit a brief statement of your reason for applying.

Nanoparticle Distribution in Tissue and Organs

Nanoparticle distribution in the posterior segment of the eye. Nanoparticles accumulate in the endothelial cells of the choriocapillaris (CC). Sclera (S); retinal pigment epithelium (RPE). Fluorescent nanoparticles (red); DAPI nuclei staining (blue); tissue autofluorescence (gray). (Figure taken from: Pollinger et al. Proc. Natl. Acad. Sci. 2013, 110, 6115–6120, www.pnas.org/content/110/15/6115).

Nanoparticles are subject to limited biodistribution due to their size and physicochemical properties which is a severe handicap for their therapeutic application. An exception is tumor tissue into which nanoparticles may extravasate through endothelial fenestrations. These openings stem from changes in malignant tissue blood vessels, particularly in capillaries. But endothelial fenestrations also exist in the capillaries of healthy tissues such as the kidneys’ glomeruli and the choroid... more.