Prof. Dr. Peter Flor

Peer-reviewed publications – Prof. Dr. Peter J. Flor

1

Novel Inhibitory Site Revealed by XAP044 Mode of Action on the Metabotropic Glutamate 7 Receptor Venus Flytrap Domain. (externer Link, ?ffnet neues Fenster)

Cristiano N, Cabayé A, Brabet I, Glatthar R, Tora A, Goudet C, Bertrand HO, Goupil-Lamy A, Flor PJ, Pin JP, McCort-Tranchepain I, Acher FC. J Med Chem. 2024 May 1. doi: 10.1021/acs.jmedchem.3c01924. Online ahead of print. PMID: 38691510

2

Blocking Metabotropic Glutamate Receptor Subtype 7 via the Venus Flytrap Domain Promotes a Chronic Stress-Resilient Phenotype in Mice. (externer Link, ?ffnet neues Fenster)

Estrela KAR, Senninger L, Arndt J, Kabas M, Schmid F, Dillmann L, Auer S, Stepfer T, Flor PJ, Uschold-Schmidt N. Cells. 2022 Jun 2;11(11):1817. doi: 10.3390/cells11111817. PMID: 35681512 Free PMC article.

3

Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice. (externer Link, ?ffnet neues Fenster)

Gryksa K, Mittmann L, Bauer A, Peterlik D, Flor PJ, Uschold-Schmidt N, Bosch OJ. Genes Brain Behav. 2020 Jan;19(1):e12627. doi: 10.1111/gbb.12627. Epub 2019 Dec 14. PMID: 31793148 Free article.

4

Pharmacological modulation of metabotropic glutamate receptor subtype 5 and 7 impairs extinction of social fear in a time-point-dependent manner. (externer Link, ?ffnet neues Fenster)

Slattery DA, Neumann ID, Flor PJ, Zoicas I. Behav Brain Res. 2017 Jun 15;328:57-61. doi: 10.1016/j.bbr.2017.04.010. Epub 2017 Apr 7. PMID: 28392321

5

Individual differences in stress vulnerability: The role of gut pathobionts in stress-induced colitis. (externer Link, ?ffnet neues Fenster)

Langgartner D, Peterlik D, Foertsch S, Füchsl AM, Brokmann P, Flor PJ, Shen Z, Fox JG, Uschold-Schmidt N, Lowry CA, Reber SO. Brain Behav Immun. 2017 Aug;64:23-32. doi: 10.1016/j.bbi.2016.12.019. Epub 2016 Dec 21. PMID: 28012830

6

Type-7 metabotropic glutamate receptors negatively regulate α₁-adrenergic receptor signalling. (externer Link, ?ffnet neues Fenster)

Iacovelli L, Di Menna L, Peterlik D, Stangl C, Orlando R, Molinaro G, De Blasi A, Bruno V, Battaglia G, Flor PJ, Uschold-Schmidt N, Nicoletti F. Neuropharmacology. 2017 Feb;113(Pt A):343-353. doi: 10.1016/j.neuropharm.2016.10.018. Epub 2016 Oct 18. PMID: 27769854

7

Blocking metabotropic glutamate receptor subtype 5 relieves maladaptive chronic stress consequences. (externer Link, ?ffnet neues Fenster)

Peterlik D, Stangl C, Bauer A, Bludau A, Keller J, Grabski D, Killian T, Schmidt D, Zajicek F, Jaeschke G, Lindemann L, Reber SO, Flor PJ, Uschold-Schmidt N. Brain Behav Immun. 2017 Jan;59:79-92. doi: 10.1016/j.bbi.2016.08.007. Epub 2016 Aug 11. PMID: 27524668

8

The Emerging Role of Metabotropic Glutamate Receptors in the Pathophysiology of Chronic Stress-Related Disorders. (externer Link, ?ffnet neues Fenster)

Peterlik D, Flor PJ, Uschold-Schmidt N. Curr Neuropharmacol. 2016;14(5):514-39. doi: 10.2174/1570159x13666150515234920. PMID: 27296643 Free PMC article. Review.

9

Relief from detrimental consequences of chronic psychosocial stress in mice deficient for the metabotropic glutamate receptor subtype 7. (externer Link, ?ffnet neues Fenster)

Peterlik D, Stangl C, Bludau A, Grabski D, Strasser R, Schmidt D, Flor PJ, Uschold-Schmidt N. Neuropharmacology. 2017 Mar 15;115:139-148. doi: 10.1016/j.neuropharm.2016.04.036. Epub 2016 May 14. PMID: 27188844

10

Metabotropic Glutamate Receptor Subtype 7 in the Bed Nucleus of the Stria Terminalis is Essential for Intermale Aggression. (externer Link, ?ffnet neues Fenster)

Masugi-Tokita M, Flor PJ, Kawata M. Neuropsychopharmacology. 2016 Feb;41(3):726-35. doi: 10.1038/npp.2015.198. Epub 2015 Jul 7. PMID: 26149357 Free PMC article.

11

AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: identification, SAR and pharmacological characterization. (externer Link, ?ffnet neues Fenster)

Vranesic I, Ofner S, Flor PJ, Bilbe G, Bouhelal R, Enz A, Desrayaud S, McAllister K, Kuhn R, Gasparini F. Bioorg Med Chem. 2014 Nov 1;22(21):5790-803. doi: 10.1016/j.bmc.2014.09.033. Epub 2014 Sep 20. PMID: 25316499

12

Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. (externer Link, ?ffnet neues Fenster)

Gee CE, Peterlik D, Neuh?user C, Bouhelal R, Kaupmann K, Laue G, Uschold-Schmidt N, Feuerbach D, Zimmermann K, Ofner S, Cryan JF, van der Putten H, Fendt M, Vranesic I, Glatthar R, Flor PJ. J Biol Chem. 2014 Apr 18;289(16):10975-10987. doi: 10.1074/jbc.M113.542654. Epub 2014 Mar 4. PMID: 24596089 Free PMC article.

13

Differential roles of mGlu(7) and mGlu(8) in amygdala-dependent behavior and physiology. (externer Link, ?ffnet neues Fenster)

Fendt M, Imobersteg S, Peterlik D, Chaperon F, Mattes C, Wittmann C, Olpe HR, Mosbacher J, Vranesic I, van der Putten H, McAllister KH, Flor PJ, Gee CE. Neuropharmacology. 2013 Sep;72:215-23. doi: 10.1016/j.neuropharm.2013.04.052. Epub 2013 May 7. PMID: 23664812

14

Adult siRNA-induced knockdown of mGlu7 receptors reduces anxiety in the mouse. (externer Link, ?ffnet neues Fenster)

O'Connor RM, Thakker DR, Schmutz M, van der Putten H, Hoyer D, Flor PJ, Cryan JF. Neuropharmacology. 2013 Sep;72:66-73. doi: 10.1016/j.neuropharm.2013.03.028. Epub 2013 Apr 17. PMID: 23603202

15

Differential effects of baclofen and oxytocin on the increased ethanol consumption following chronic psychosocial stress in mice. (externer Link, ?ffnet neues Fenster)

Peters S, Slattery DA, Flor PJ, Neumann ID, Reber SO. Addict Biol. 2013 Jan;18(1):66-77. doi: 10.1111/adb.12001. Epub 2012 Nov 6. PMID: 23126471

16

Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7. (externer Link, ?ffnet neues Fenster)

Ullmer C, Zoffmann S, Bohrmann B, Matile H, Lindemann L, Flor P, Malherbe P. Br J Pharmacol. 2012 Dec;167(7):1448-66. doi: 10.1111/j.1476-5381.2012.02090.x. PMID: 22747985 Free PMC article.

17

Orthosteric versus allosteric GPCR activation: the great challenge of group-III mGluRs. (externer Link, ?ffnet neues Fenster)

Flor PJ, Acher FC. Biochem Pharmacol. 2012 Aug 15;84(4):414-24. doi: 10.1016/j.bcp.2012.04.013. Epub 2012 Apr 24. PMID: 22554564 Review.

18

Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear. (externer Link, ?ffnet neues Fenster)

Toth I, Dietz M, Peterlik D, Huber SE, Fendt M, Neumann ID, Flor PJ, Slattery DA. Neuropharmacology. 2012 Mar;62(4):1619-26. doi: 10.1016/j.neuropharm.2011.10.021. Epub 2011 Nov 10. PMID: 22079159

19

Pharmacological modulation of mGluR7 with AMN082 and MMPIP exerts specific influences on alcohol consumption and preference in rats. (externer Link, ?ffnet neues Fenster)

Bahi A, Fizia K, Dietz M, Gasparini F, Flor PJ. Addict Biol. 2012 Mar;17(2):235-47. doi: 10.1111/j.1369-1600.2010.00310.x. Epub 2011 Mar 11. PMID: 21392179

20

Exciting times beyond the brain: metabotropic glutamate receptors in peripheral and non-neural tissues. (externer Link, ?ffnet neues Fenster)

Julio-Pieper M, Flor PJ, Dinan TG, Cryan JF. Pharmacol Rev. 2011 Mar;63(1):35-58. doi: 10.1124/pr.110.004036. Epub 2011 Jan 12. PMID: 21228260 Review.

21

Metabotropic glutamate receptor 7: at the interface of cognition and emotion. (externer Link, ?ffnet neues Fenster)

O'Connor RM, Finger BC, Flor PJ, Cryan JF. Eur J Pharmacol. 2010 Aug 10;639(1-3):123-31. doi: 10.1016/j.ejphar.2010.02.059. Epub 2010 Apr 2. PMID: 20371242 Review.

22

Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease. (externer Link, ?ffnet neues Fenster)

Greco B, Lopez S, van der Putten H, Flor PJ, Amalric M. J Pharmacol Exp Ther. 2010 Mar;332(3):1064-71. doi: 10.1124/jpet.109.162115. Epub 2009 Nov 25. PMID: 19940105

23

Selective activation of metabotropic G-protein-coupled glutamate 7 receptor elicits anxiolytic-like effects in mice by modulating GABAergic neurotransmission. (externer Link, ?ffnet neues Fenster)

Stachowicz K, Bra?ski P, K?ak K, van der Putten H, Cryan JF, Flor PJ, Andrzej P. Behav Pharmacol. 2008 Sep;19(5-6):597-603. doi: 10.1097/FBP.0b013e32830cd839. PMID: 18690114

24

Amygdaloid metabotropic glutamate receptor subtype 7 is involved in the acquisition of conditioned fear. (externer Link, ?ffnet neues Fenster)

Siegl S, Flor PJ, Fendt M. Neuroreport. 2008 Jul 16;19(11):1147-50. doi: 10.1097/WNR.0b013e328307f295. PMID: 18596617

25

mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity. (externer Link, ?ffnet neues Fenster)

Fendt M, Schmid S, Thakker DR, Jacobson LH, Yamamoto R, Mitsukawa K, Maier R, Natt F, Hüsken D, Kelly PH, McAllister KH, Hoyer D, van der Putten H, Cryan JF, Flor PJ. Mol Psychiatry. 2008 Oct;13(10):970-9. doi: 10.1038/sj.mp.4002073. Epub 2007 Aug 21. PMID: 17712315

26

Activation of the mGlu7 receptor elicits antidepressant-like effects in mice. (externer Link, ?ffnet neues Fenster)

Palucha A, Klak K, Branski P, van der Putten H, Flor PJ, Pilc A. Psychopharmacology (Berl). 2007 Nov;194(4):555-62. doi: 10.1007/s00213-007-0856-2. Epub 2007 Jul 12. PMID: 17622518

27

Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy. (externer Link, ?ffnet neues Fenster)

Pitsch J, Schoch S, Gueler N, Flor PJ, van der Putten H, Becker AJ. Neurobiol Dis. 2007 Jun;26(3):623-33. doi: 10.1016/j.nbd.2007.03.003. Epub 2007 Mar 16. PMID: 17446080

28

Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking. (externer Link, ?ffnet neues Fenster)

Zeitz C, Forster U, Neidhardt J, Feil S, K?lin S, Leifert D, Flor PJ, Berger W. Hum Mutat. 2007 Aug;28(8):771-80. doi: 10.1002/humu.20499. PMID: 17405131

29

Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines. (externer Link, ?ffnet neues Fenster)

Marinozzi M, Serpi M, Amori L, Gavilan Diaz M, Costantino G, Meyer U, Flor PJ, Gasparini F, Heckendorn R, Kuhn R, Giorgi G, Hermit MB, Thomsen C, Pellicciari R. Bioorg Med Chem. 2007 May 1;15(9):3161-70. doi: 10.1016/j.bmc.2007.02.040. Epub 2007 Feb 22. PMID: 17350267

30

A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. (externer Link, ?ffnet neues Fenster)

Mitsukawa K, Yamamoto R, Ofner S, Nozulak J, Pescott O, Lukic S, Stoehr N, Mombereau C, Kuhn R, McAllister KH, van der Putten H, Cryan JF, Flor PJ. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18712-7. doi: 10.1073/pnas.0508063102. Epub 2005 Dec 9. PMID: 16339898 Free PMC article.

31

Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels: implications for stress-related psychiatric disorders. (externer Link, ?ffnet neues Fenster)

Mitsukawa K, Mombereau C, L?tscher E, Uzunov DP, van der Putten H, Flor PJ, Cryan JF. Neuropsychopharmacology. 2006 Jun;31(6):1112-22. doi: 10.1038/sj.npp.1300926. PMID: 16237391

32

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection. (externer Link, ?ffnet neues Fenster)

Maj M, Bruno V, Dragic Z, Yamamoto R, Battaglia G, Inderbitzin W, Stoehr N, Stein T, Gasparini F, Vranesic I, Kuhn R, Nicoletti F, Flor PJ. Neuropharmacology. 2003 Dec;45(7):895-906. doi: 10.1016/s0028-3908(03)00271-5. PMID: 14573382

33

Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7. (externer Link, ?ffnet neues Fenster)

Cryan JF, Kelly PH, Neijt HC, Sansig G, Flor PJ, van Der Putten H. Eur J Neurosci. 2003 Jun;17(11):2409-17. doi: 10.1046/j.1460-9568.2003.02667.x. PMID: 12814372

34

Neuroprotective activity of metabotropic glutamate receptor ligands. (externer Link, ?ffnet neues Fenster)

Flor PJ, Battaglia G, Nicoletti F, Gasparini F, Bruno V. Adv Exp Med Biol. 2002;513:197-223. doi: 10.1007/978-1-4615-0123-7_7. PMID: 12575822 Review.

35

In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: review article. (externer Link, ?ffnet neues Fenster)

Kuhn R, Pagano A, Stoehr N, Vranesic I, Flor PJ, Lingenh?hl K, Spooren W, Gentsch C, Vassout A, Pilc A, Gasparini F. Amino Acids. 2002;23(1-3):207-11. doi: 10.1007/s00726-001-0130-6. PMID: 12373539 Review.

36

[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5. (externer Link, ?ffnet neues Fenster)

Gasparini F, Andres H, Flor PJ, Heinrich M, Inderbitzin W, Lingenh?hl K, Müller H, Munk VC, Omilusik K, Stierlin C, Stoehr N, Vranesic I, Kuhn R. Bioorg Med Chem Lett. 2002 Feb 11;12(3):407-9. doi: 10.1016/s0960-894x(01)00767-3. PMID: 11814808

37

Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. (externer Link, ?ffnet neues Fenster)

Sansig G, Bushell TJ, Clarke VR, Rozov A, Burnashev N, Portet C, Gasparini F, Schmutz M, Klebs K, Shigemoto R, Flor PJ, Kuhn R, Knoepfel T, Schroeder M, Hampson DR, Collett VJ, Zhang C, Duvoisin RM, Collingridge GL, van Der Putten H. J Neurosci. 2001 Nov 15;21(22):8734-45. doi: 10.1523/JNEUROSCI.21-22-08734.2001. PMID: 11698585 Free PMC article.

38

Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs. (externer Link, ?ffnet neues Fenster)

Bruno V, Battaglia G, Copani A, D'Onofrio M, Di Iorio P, De Blasi A, Melchiorri D, Flor PJ, Nicoletti F. J Cereb Blood Flow Metab. 2001 Sep;21(9):1013-33. doi: 10.1097/00004647-200109000-00001. PMID: 11524608 Review.

39

Discovery and characterization of non-competitive antagonists of group I metabotropic glutamate receptors. (externer Link, ?ffnet neues Fenster)

Gasparini F, Floersheim P, Flor PJ, Heinrich M, Inderbitzin W, Ott D, Pagano A, Stierlin C, Stoehr N, Vranesic I, Kuhn R. Farmaco. 2001 Jan-Feb;56(1-2):95-9. doi: 10.1016/s0014-827x(01)01008-4. PMID: 11347975 Review.

40

An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors. (externer Link, ?ffnet neues Fenster)

Bruno V, Battaglia G, Copani A, Cespédes VM, Galindo MF, Ce?a V, Sánchez-Prieto J, Gasparini F, Kuhn R, Flor PJ, Nicoletti F. Eur J Neurosci. 2001 Apr;13(8):1469-78. doi: 10.1046/j.0953-816x.2001.01541.x. PMID: 11328342

41

Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino- 1a, 2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester. (externer Link, ?ffnet neues Fenster)

Ott D, Floersheim P, Inderbitzin W, Stoehr N, Francotte E, Lecis G, Richert P, Rihs G, Flor PJ, Kuhn R, Gasparini F. J Med Chem. 2000 Nov 16;43(23):4428-36. doi: 10.1021/jm0009944. PMID: 11087567

42

Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain. (externer Link, ?ffnet neues Fenster)

Walker K, Bowes M, Panesar M, Davis A, Gentry C, Kesingland A, Gasparini F, Spooren W, Stoehr N, Pagano A, Flor PJ, Vranesic I, Lingenhoehl K, Johnson EC, Varney M, Urban L, Kuhn R. Neuropharmacology. 2001;40(1):1-9. doi: 10.1016/s0028-3908(00)00113-1. PMID: 11077065

43

Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective. (externer Link, ?ffnet neues Fenster)

Bruno V, Ksiazek I, Battaglia G, Lukic S, Leonhardt T, Sauer D, Gasparini F, Kuhn R, Nicoletti F, Flor PJ. Neuropharmacology. 2000 Sep;39(12):2223-30. doi: 10.1016/s0028-3908(00)00079-4. PMID: 10974306

44

Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death. (externer Link, ?ffnet neues Fenster)

Bruno V, Battaglia G, Ksiazek I, van der Putten H, Catania MV, Giuffrida R, Lukic S, Leonhardt T, Inderbitzin W, Gasparini F, Kuhn R, Hampson DR, Nicoletti F, Flor PJ. J Neurosci. 2000 Sep 1;20(17):6413-20. doi: 10.1523/JNEUROSCI.20-17-06413.2000. PMID: 10964947 Free PMC article.

45

The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors. (externer Link, ?ffnet neues Fenster)

Pagano A, Ruegg D, Litschig S, Stoehr N, Stierlin C, Heinrich M, Floersheim P, Prezèau L, Carroll F, Pin JP, Cambria A, Vranesic I, Flor PJ, Gasparini F, Kuhn R. J Biol Chem. 2000 Oct 27;275(43):33750-8. doi: 10.1074/jbc.M006230200. PMID: 10934211 Free article.

46

Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III. (externer Link, ?ffnet neues Fenster)

Amori L, Costantino G, Marinozzi M, Pellicciari R, Gasparini F, Flor PJ, Kuhn R, Vranesic I. Bioorg Med Chem Lett. 2000 Jul 3;10(13):1447-50. doi: 10.1016/s0960-894x(00)00247-x. PMID: 10888329

47

(+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist. (externer Link, ?ffnet neues Fenster)

Gasparini F, Inderbitzin W, Francotte E, Lecis G, Richert P, Dragic Z, Kuhn R, Flor PJ. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1241-4. doi: 10.1016/s0960-894x(00)00197-9. PMID: 10866390

48

Distinct influence of the group III metabotropic glutamate receptor agonist (R,S)-4-phosphonophenylglycine [(R,S)-PPG] on different forms of neuronal damage. (externer Link, ?ffnet neues Fenster)

Henrich-Noack P, Flor PJ, Sabelhaus CF, Prass K, Dirnagl U, Gasparini F, Sauter A, Rudin M, Reymann KG. Neuropharmacology. 2000 Mar 3;39(5):911-7. doi: 10.1016/s0028-3908(99)00256-7. PMID: 10699457

49

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. (externer Link, ?ffnet neues Fenster)

Gasparini F, Lingenh?hl K, Stoehr N, Flor PJ, Heinrich M, Vranesic I, Biollaz M, Allgeier H, Heckendorn R, Urwyler S, Varney MA, Johnson EC, Hess SD, Rao SP, Sacaan AI, Santori EM, Veli?elebi G, Kuhn R. Neuropharmacology. 1999 Oct;38(10):1493-503. doi: 10.1016/s0028-3908(99)00082-9. PMID: 10530811

50

SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. (externer Link, ?ffnet neues Fenster)

Varney MA, Cosford ND, Jachec C, Rao SP, Sacaan A, Lin FF, Bleicher L, Santori EM, Flor PJ, Allgeier H, Gasparini F, Kuhn R, Hess SD, Veli?elebi G, Johnson EC. J Pharmacol Exp Ther. 1999 Jul;290(1):170-81. PMID: 10381773

51

(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. (externer Link, ?ffnet neues Fenster)

Gasparini F, Bruno V, Battaglia G, Lukic S, Leonhardt T, Inderbitzin W, Laurie D, Sommer B, Varney MA, Hess SD, Johnson EC, Kuhn R, Urwyler S, Sauer D, Portet C, Schmutz M, Nicoletti F, Flor PJ. J Pharmacol Exp Ther. 1999 Jun;289(3):1678-87. PMID: 10336568

52

CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. (externer Link, ?ffnet neues Fenster)

Litschig S, Gasparini F, Rueegg D, Stoehr N, Flor PJ, Vranesic I, Prézeau L, Pin JP, Thomsen C, Kuhn R. Mol Pharmacol. 1999 Mar;55(3):453-61. PMID: 10051528

53

Functional coupling of a human retinal metabotropic glutamate receptor (hmGluR6) to bovine rod transducin and rat Go in an in vitro reconstitution system. (externer Link, ?ffnet neues Fenster)

Weng K, Lu C, Daggett LP, Kuhn R, Flor PJ, Johnson EC, Robinson PR. J Biol Chem. 1997 Dec 26;272(52):33100-4. doi: 10.1074/jbc.272.52.33100. PMID: 9407094 Free article.

54

Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. (externer Link, ?ffnet neues Fenster)

Shigemoto R, Kinoshita A, Wada E, Nomura S, Ohishi H, Takada M, Flor PJ, Neki A, Abe T, Nakanishi S, Mizuno N. J Neurosci. 1997 Oct 1;17(19):7503-22. doi: 10.1523/JNEUROSCI.17-19-07503.1997. PMID: 9295396 Free PMC article.

55

Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. (externer Link, ?ffnet neues Fenster)

Kaupmann K, Huggel K, Heid J, Flor PJ, Bischoff S, Mickel SJ, McMaster G, Angst C, Bittiger H, Froestl W, Bettler B. Nature. 1997 Mar 20;386(6622):239-46. doi: 10.1038/386239a0. PMID: 9069281

56

A novel splice variant of a metabotropic glutamate receptor, human mGluR7b. (externer Link, ?ffnet neues Fenster)

Flor PJ, Van Der Putten H, Rüegg D, Lukic S, Leonhardt T, Bence M, Sansig G, Kn?pfel T, Kuhn R. Neuropharmacology. 1997 Feb;36(2):153-9. doi: 10.1016/s0028-3908(96)00176-1. PMID: 9144652

57

The C-terminal domain of the mGluR1 metabotropic glutamate receptor affects sensitivity to agonists. (externer Link, ?ffnet neues Fenster)

Flor PJ, Gomeza J, Tones MA, Kuhn R, Pin JP, Kn?pfel T. J Neurochem. 1996 Jul;67(1):58-63. doi: 10.1046/j.1471-4159.1996.67010058.x. PMID: 8667026

58

The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain. (externer Link, ?ffnet neues Fenster)

Tones MA, Bendali N, Flor PJ, Kn?pfel T, Kuhn R. Neuroreport. 1995 Dec 29;7(1):117-20. PMID: 8742431

59

Pharmacological characterization of MCCG and MAP4 at the mGluR1b, mGluR2 and mGluR4a human metabotropic glutamate receptor subtypes. (externer Link, ?ffnet neues Fenster)

Kn?pfel T, Lukic S, Leonard T, Flor PJ, Kuhn R, Gasparini F. Neuropharmacology. 1995 Aug;34(8):1099-102. doi: 10.1016/0028-3908(95)00111-i. PMID: 8532159

60

Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2. (externer Link, ?ffnet neues Fenster)

Flor PJ, Lindauer K, Püttner I, Rüegg D, Lukic S, Kn?pfel T, Kuhn R. Eur J Neurosci. 1995 Apr 1;7(4):622-9. doi: 10.1111/j.1460-9568.1995.tb00666.x. PMID: 7620613

61

Profiling of trans-azetidine-2,4-dicarboxylic acid at the human metabotropic glutamate receptors mGlu1b, -2, -4a and -5a. (externer Link, ?ffnet neues Fenster)

Kn?pfel T, Sakaki J, Flor PJ, Baumann P, Sacaan AI, Veli?elebi G, Kuhn R, Allgeier H. Eur J Pharmacol. 1995 Feb 15;288(3):389-92. doi: 10.1016/0922-4106(95)90054-3. PMID: 7774685

62

Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4. (externer Link, ?ffnet neues Fenster)

Flor PJ, Lukic S, Rüegg D, Leonhardt T, Kn?pfel T, Kuhn R. Neuropharmacology. 1995 Feb;34(2):149-55. doi: 10.1016/0028-3908(94)00149-m. PMID: 7617140

63

Characterization of the Antirrhinum floral homeotic MADS-box gene deficiens: evidence for DNA binding and autoregulation of its persistent expression throughout flower development. (externer Link, ?ffnet neues Fenster)

Schwarz-Sommer Z, Hue I, Huijser P, Flor PJ, Hansen R, Tetens F, L?nnig WE, Saedler H, Sommer H. EMBO J. 1992 Jan;11(1):251-63. doi: 10.1002/j.1460-2075.1992.tb05048.x. PMID: 1346760 Free PMC article.

64

A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing. (externer Link, ?ffnet neues Fenster)

Flor PJ, Flanegan JB, Cech TR. EMBO J. 1989 Nov;8(11):3391-9. doi: 10.1002/j.1460-2075.1989.tb08503.x. PMID: 2684642 Free PMC article.

Alumni
 

    Dr. rer. nat. Nicole Uschold-Schmidt
    Katharina Fizia
    Karolyne Estrela
    Sabina Senft
    Marina Sterr
    MSc Lisa Senninger
    BSc Thomas Stepfer
    BSc Sabrina Jesko
    BSc Josephine Arndt
    BSc Melanie Kabas
    BSc Ferdinand Schmid
    BSc Larissa Dillmann
    BSc Sophia Auer
    Dr. rer. nat. Daniel Peterlik
    MSc Franziska Zajicek
    MSc Christina Stangl
    MSc Robert Strasser
    MSc Amelie Bauer
    MSc Katharina Gryksa
    BSc Jana Keller
    BSc Dominik Grabski
    Dr. rer. nat. Anna Bludau
    Dipl. Biochem. Christoph Neuh?user
    BSc Andreas Grasskamp
    BSc Ramona Oeller
    MSc Tobias Killian
    MSc Sabine Huber
    BSc Silke Eggerstorfer
    BSc Angelika Bauer
    BSc Andrea Dillinger
    BSc Thomas Neder
    Dr. Amine Bahi
    Dipl.-Biol. Lisa Adelfinger
    BSc Michael Linsmeier
    Dipl.-Biol. Monika Dietz