Biophysics

Prof. Dr Remco Sprangers (external link, opens in a new window)

Prof. Dr Christine Ziegler (external link, opens in a new window)

You have to choose the theoretical module and one practical module.

For the practical module laboratory courses are acceptet from following groups:

Prof. Till Rudack(link to the group (external link, opens in a new window)) (Laboratory course: Sequence- and structure-based computational biology

Prof. Dr Christoph Engel link! (external link, opens in a new window) (Laboratory course: Structural biochemistry, 54256)

Prof. Dr André Stiel Stiel-lab.de (external link, opens in a new window)(Laboratory course: Protein Engineering for Superresolution Microscopy, 54484)

TM Structural Biology/Biophysics I and II

BIO-M-TM-BP

Detailed module description - pdf (external link, opens in a new window)

Person in charge: Prof. Dr Christine Ziegler, Prof. Dr Remco Sprangers

Module contents
Introduction into the physical principles of protein function in trnacription, RNA interactions, membrane transport and signal transduction, NMR to understand structure and dynamics of proteins High-pressure NMR to investigate the conformational landscape of proteins High-resolution structures by X-ray diffraction and crystallography Time-resolved structures by free electron laser Single particle analysis and cryo-electron microscopy Homology modelling and structure modelling Electron tomography, scanning electron microscopy and correlative light-and electron microscopy FRET and TIRD microscopy Presentation and discussion of a research based topic in the field of structural biology with a focus on the methods discussed in the lecture: NMR, X-ray, EM, FRET
Module components
1. at least two lectures from the following (WS and SS): Structural Biology I & II or Physical Biochemistry I & II 2. one seminar from the following (WS and SS): Structural Biology I & II or Physical Biochemistry I & II In the seminar a seminar presentation has to be held and registered in Flexnow as an ungraded study achievement (Studienleistung). Note! If you are not sure what lectures and seminar to select, please contact the person in charge of the module. The selection may depend on the examiner you choose for the module examination.
Module examination
30 min oral examination (graded) Examiner: Prof. Dr Remco Sprangers Prof. Dr Christine Ziegler Prof. Till Rudack The student can choose the examiner. Please get in contact with the examiner of your choice to arrange a date of the oral examination, than register the examination in flexnow.

PM Structure Biology of Membrane Proteins

BIO-M-PM-MP

Prof. Dr Christine Ziegler(link to research group (external link, opens in a new window))

Detailed module description - pdf (external link, opens in a new window)

Module contents
Expression and purification of membrane proteins Single Particle Data collection and electron microscopy Two-dimensional and three-dimensional membrane protein crystallisation Introduction into EM and X-ray data analysis Homology modelling as tool for structure determination at low resolution Presentation and discussion of own experimental gained data
Module components
Laboratory course (6 weeks) with seminar: Structure Biology of Membrane Proteins
Module examination
Portfolio examination (graded)

PM Biomolecular NMR-Spectroscopy

BIO-M-PM-S

Detailed module description - pdf (external link, opens in a new window)

Prof. Dr Remco Sprangers (link to research group) (external link, opens in a new window)

Module contents
Expression and purification of NMR isotope labelled proteins Collection of 1 and 2 dimensional NMR experiments Analysis of multidimensional NMR spectra Collection and analysis of NMR data to assess protein dynamics Performance of NMR titration data to extract binding characteristics Shift of the conformational equilibrium using high pressure NMR Presentation and discussion of own experimental gained data
Module components
Laboratory course (6 weeks) with seminar: Biomolecular NMR-Spectroscopy
Module examination
Portfolio examination (graded)

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